Transcranial Magnetic Stimulation - Clinical Trials for Treating Schizophrenia

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Transcranial Magnetic Stimulation - Clinical Trials for Treating Schizophrenia

The total number of completed TMS trials for treating schizophrenia is 15, while the number of current trials equates to 9. We have listed these trials along with the lead reasearchers and the active years of the trials (if they are completed). Many of these trials have similar goals and strategies of treatment.

THERAPEUTIC EFFICACY OF TRANSCRANIAL MAGNETIC STIMULATION IN SCHIZOPHRENIA

Lead researcher: Mark Halko, Ph.D.
Start date: February 2012
End date: November 2015
Status: Completed, Has Results

This study demonstrated the safety of image-guided theta burst stimulation over the cerebellar vermis in eight schizophrenic patients.

EFFECT OF REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION ON RESTING STATE BRAIN ACTIVITY IN SCHIZOPHRENIA

Lead researcher: Erick Messias, MD, MPH, PhD
Start date: June 2012
End date: August 2015
Status: Completed, Has Results
This study involved comparing the efficacy of low and high-frequency Transcranial Magnetic Stimulation. Researchers tried to determine whether high or low frequencies will work best.

NEUROCOGNITIVE DEFICITS AND FUNCTION IN SCHIZOPHRENIA WITH TRANSCRANIAL MAGNETIC STIMULATION

Lead researcher: Jong H. Yoon, MD
Start date: August 1, 2017
End date: July 1, 2019 (estimated)
Status: Current
The researchers conduct small-scale studies involving rTMS testing with veterans. Neurophysiologic experiments determine whether neural makers of abnormal brain function responds well to rTMS.

TREATMENT OF NEGATIVE SYMPTOMS OF SCHIZOPHRENIA WITH TRANSCRANIAL MAGNETIC STIMULATION (TMS)

Lead researcher: Arielle D. Stanford, MD
Start date: September 2004
End date: June 2011
Status: Terminated, Has Results
This study targets negative symptoms of schizophrenia-like social deficits and dysfunction in relation to rTMS treatment. This includes isolating the dorsolateral prefrontal cortex and the left inferior parietal lobe.

CEREBELLAR RTMS FOR THE TREATMENT OF SCHIZOPHRENIC PATIENTS

Lead researcher: Alvaro Pascual-Leone, MD, PhD
Start date: February 2008
End date: April 2009
Status: Completed, Has Results
Participants of this study receive 10 TMS sessions twice a day, Monday through Friday, in burst patterns. The TMS was administered via MaProx100 device to the vermis of the cerebellum.

TRANSCRANIAL MAGNETIC STIMULATION FOR THE TREATMENT OF AUDITORY HALLUCINATIONS IN SCHIZOPHRENIA

Lead researcher: Stephan F Taylor, M.D.
Start date: May 2011
End date: August 2012
Status: Completed
This trial involves low-frequency rTMS treatments administered during 10 daily 20-minute sessions. They were applied to the secondary auditory cortex and scanned via fMRI to identify the scalp location overlying the targeted cortex.

TMS ENHANCEMENT OF VISUAL PLASTICITY IN SCHIZOPHRENIA

Lead researcher: Laura M Rowland, PhD
Start date: September 27, 2017
End date: November 25, 2019 (estimated)
Status: Current
The purpose of this study is to determine whether TMS enhances the visual plasticity in schizophrenic patients. The project hopes to provide a better understanding of the mechanisms responsible for memory and learning deficits in schizophrenia.

REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION FOR "VOICES"

Lead researcher: Ralph Hoffman
Start date: December 1999
End date: June 2005
Status: Completed, Has Results
This study aimed to determine whether repetitive TMS treatment affects refractory auditory hallucinations in schizophrenic patients.

TRANSCRANIAL MAGNETIC STIMULATION FOR "VOICES"

Lead researcher: Ralph E. Hoffman, MD
Start date: February 2006
End date: September 2011
Status: Completed, Has Results
This is a similar study to the previously listed case which aims to reduce "voices" and other symptoms of schizophrenia through TMS treatments. It also involves contact with participants for up to one year after the trial to determine effectiveness.

TMS FOR SYMPTOM REDUCTION IN SCHIZOPHRENIA

Lead researcher: L E Hong, MD
Start date: October 2016
End date: July 2021 (estimated)
Status: Current
This trial includes TMS treatments aimed to reduce auditory hallucinations involved with schizophrenia. An electroencephalogram is also used to evaluate electrical activity within the brain which corresponds to the treatment.

TRANSCRANIAL MAGNETIC STIMULATION (TMS) TREATMENT FOR PATIENTS WITH PERSISTENT AUDITORY HALLUCINATIONS

Lead researcher: Ralph Edward Hoffman
Start date: July 2002
End date: June 2004
Status: Completed
A study aimed to determine if low-frequency rTMS to brain areas responsible for speech can treat auditory hallucinations related to schizophrenia.

BILATERAL REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION FOR AUDITORY HALLUCINATIONS

Lead researcher: Ralph Hoffman, MD
Start date: October 2007
End date: estimated for 2017, but still listed as recruiting - assuming still active
Status: Current
This trial involves an extension of an ongoing trial initiated in 2006. The primary objective is to determine the efficacy of RTMS in curbing auditory hallucinations. Treatment is delivered to a part of the left temporal lobe called Wernicke's area, and a similar region in the right temporal lobe.

THETA BURST STIMULATION FOR SCHIZOPHRENIA

Lead researcher: Gopalkumar Rakesh, MD
Start date: October 24, 2017
End date: June 30, 2018 (estimated)
Status: Current
This study analyzes the effects of TMS and Thea Burst Stimulation on schizophrenic deficits including working memory, cognition and cortical inhibition.

TARGETING CEREBELLUM TO TREAT PSYCHOSIS: A TRANSCRANIAL MAGNETIC STIMULATION (TMS) STUDY

Lead researcher: Ann K Shinn, MD, MPH
Start date: January 2016
End date: December 2018 (estimated)
Status: Current

This trial investigates the impact of TMS on schizophrenic patients experiencing deficiencies with time perception, mood, and executive function. Researchers believe that stimulating the cerebellum will normalize disease-relevant outcomes.

CIRCUITRY-GUIDED SMOKING CESSATION IN SCHIZOPHRENIA

Lead researcher: Xiaoming Du, MD
Start date: March 1, 2018
End date: October 1, 2022 (estimated)
Status: Current
This study attempts to target nicotine addiction in schizophrenic patients with repetitive transcranial magnetic stimulation guided by MRI. Researchers believe the neural circuitry associated with schizophrenia is associated to that of nicotine addiction.

TREATING REFRACTORY SCHIZOPHRENIA WITH RTMS

Lead researcher: Robert Buchanan, MD
Start date: August 2014
End date: May 2018 (estimated)
Status: Current

This trial involves treating schizophrenic symptoms such as social withdrawal, effective flattening, poor motivation and apathy with rTMS sessions. Cerebellar stimulation is expected to alleviate schizophrenic complications regarding "distraction."

RTMS IN FIRST EPISODE PSYCHOSIS (EMERALDTHUNDER)

Lead researcher: Michael Francis
Start date: May 2014
End date: December 2016
Status: Completed
This study analyzed the effectiveness of rTMS treatment on schizophrenic patients suffering from social and vocational impairment.

CEREBELLAR STIMULATION AND COGNITIVE CONTROL

Lead researcher: Krystal L Parker, Ph.D
Start date: November 30, 2017
End date: August 1, 2021 (estimated)
Status: Current
This study aims to determine the effectiveness of rTMS treatments on patients with schizophrenia, autism, bipolar disorder, and major depression.

CONCLUSION

There are 9 current and 15 completed TMS trials for treating schizophrenic patients. Many of these trials use the same treatment methods, but differ in their expected outcomes and the areas where treatment is administered. We have also included the names of lead researchers, as well as trial names and dates.
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