In the last couple of decades, there has been evidence to suggest that repeated transcranial magnetic stimulation (rTMS) has been effective in modestly relieving bradykinetic symptoms of Parkinson's Disease in patients.
There have been over 870 studies related to Parkinson's Disease conducted and being conducted in the United States. 27 of these trials study the impact of using TMS to target brain regions associated with the disease.
Compliant with FDA regulations, clinical trials are required to submit abbreviated results and protocols to a government database within 1 year of completion. Below are the titles, principal investigator names, and dates for both completed and active clinical trials for treating Parkinson's Disease with TMS. The primary organization credited as a collaborator on the study is listed when the lead researcher cannot be identified. 19 Completed Studies on treating Parkinson's Disease using Transcranial Magnetic Stimulation In the U.S.
Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Apathy in Parkinson's Disease. Principal Investigator: Hubert H Fernandez, MD.
Completed: December 2009.
Principal Investigator: David H. Benninger, MD.
Completed: July 2010.
Principal Investigator: David H. Benninger, MD.
Completed: September 2009.
Principal Collaborator: National Institute of Neurological Disorders and Stroke (NINDS).
Completed: March 2005.
Principal Collaborator: National Institute of Neurological Disorders and Stroke (NINDS).
Completed: September 2000.
Principal Investigator: National Institute of Neurological Disorders and Stroke (NINDS).
Completed: August 2003.
Principal Investigator: National Center for Complementary and Integrative Health (NCCIH).
Completed: April 2005.
Principal Investigator: Aparna Wagle Shukla, MD.
Completed: June 2016.
Principal Investigator: National Institute of Neurological Disorders and Stroke (NINDS).
Completed: April 2009.
Principal Investigator: John E Duda, MD, et al.
Completed: May 2011.
Principal Investigator: Alvaro Pascual-Leone, MD, PhD, et al.
Completed: June 2014.
Principal Collaborator: National Institute of Neurological Disorders and Stroke (NINDS).
Completed: October 2008.
Principal Investigator: Jou-Shin Lou, MD, PhD.
Completed: February 2007.
Principal Investigator: Daniel S. Peterson, PhD, MS.
Completed: September 2016.
Principal Collaborator: National Institute of Neurological Disorders and Stroke (NINDS).
Completed: June 2011.
Principal Collaborator: National Institute of Neurological Disorders and Stroke (NINDS).
Completed: December 2008.
Principal Collaborator: National Institute of Neurological Disorders and Stroke (NINDS).
Completed: December 2003.
Principal Investigator: Mark Hallett, MD.
Completed: n/a.
Principal Investigator: Thomas H. Mareci, PhD.
Completed: July 2017.
1 Dropped Study on treating Parkinson's Disease using Transcranial Magnetic Stimulation in the U.S.
Principal Collaborator: VA Office of Research and Development.
Status: The comorbid Parkinson's disease requirement was dropped from this study.
Completed: June 2009.
8 Current Studies on treating Parkinson's Disease using Transcranial Magnetic Stimulation in the U.S.
Principal Investigator: Alessandro Di Rocco, MD.
Status: Recruiting.
Estimated Completion: November 2018.
Principal Investigator: Milton Biagioni.
Status: Recruiting.
Estimated Completion: March 2018.
Conditions- Parkinson Disease.
Principal Collaborator: Le Bonheur Children's Hospital.
Status: Recruiting.
Estimated Completion: March 2018.
Principal Investigator: Gonzalo Revuelta, DO.
Status: Recruiting.
Estimated Completion: August 2018.
Principal Collaborator: National Institute of Neurological Disorders and Stroke (NINDS).
Status: Active, not recruiting.
Estimated Completion: January 2019.
Principal Investigator: Benzi Kluger, MD.
Status: Active, not recruiting.
Estimated Completion: December 2017.
Remotely-supervised Transcranial Direct Current Stimulation (tDCS) for At-home Treatment of Fatigue and Cognitive Slowing in Parkinson's Disease. Status: Recruiting.
Principal Investigator: Milton Biagioni, MD.
Estimated Completion: May 2018.
Principal Investigator: Krystal L. Parker, PhD.
Status: Recruiting.
Estimated Completion: August 2021.
Total Clinical Trials
There is a record of nearly 900 clinical trials in the U.S. alone that has studied the effects and treatments of Parkinson's Disease. At this time 19 trials in the U.S. have been completed on the potential for transcranial magnetic stimulation interventions to reduce symptoms, with 8 additional studies underway in the recruitment or active stages.