Transcranial Magnetic Stimulation Clinical Trials

Part
01
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Part
01

Transcranial Magnetic Stimulation - Clinical Trials for Treating Stroke Patients

There are a total of 43 completed and 26 current US clinical trial studies on Transcranial Magnetic Stimulation (TMS) as treatment for stroke patients. Your requested clinical trial information is also available for you in the attached spreadsheet.

Below you will find a deep dive of my findings.

OVERVIEW

To answer your question, I researched the national database Clinical Trials.gov by the US National Library of Medicine. I found that there are a total of 79 clinical trial studies about TMS for treating stroke patients in the US.

Of these, 43 were documented as completed while 26 were marked as current (recruiting, enrolling by invitation, active).

I have organized my findings into a spreadsheet for your convenience. Completed clinical trials are encoded in the Completed tab of the attached spreadsheet, while Current clinical trials (recruiting, enrolling by invitation, active) are encoded in the Current tab. These are presented primarily by Trial title, Lead researcher and Year with additional information.

CONCLUSION

To wrap it up, Clinical Trials.gov reports a total of 43 completed and 26 current US studies on Transcranial Magnetic Stimulation (TMS) as treatment for stroke patients. Your requested clinical trial information is also available for you in the attached spreadsheet.
Part
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Part
02

Transcranial Magnetic Stimulation - Clinical Trials for Treating Parkinson’s Disease

In the last couple of decades, there has been evidence to suggest that repeated transcranial magnetic stimulation (rTMS) has been effective in modestly relieving bradykinetic symptoms of Parkinson's Disease in patients.

There have been over 870 studies related to Parkinson's Disease conducted and being conducted in the United States. 27 of these trials study the impact of using TMS to target brain regions associated with the disease.

Compliant with FDA regulations, clinical trials are required to submit abbreviated results and protocols to a government database within 1 year of completion. Below are the titles, principal investigator names, and dates for both completed and active clinical trials for treating Parkinson's Disease with TMS. The primary organization credited as a collaborator on the study is listed when the lead researcher cannot be identified.

19 Completed Studies on treating Parkinson's Disease using Transcranial Magnetic Stimulation In the U.S.

Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Apathy in Parkinson's Disease.
Principal Investigator: Hubert H Fernandez, MD.
Completed: December 2009.

50 Hz Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Parkinson's Disease.
Principal Investigator: David H. Benninger, MD.
Completed: July 2010.

Transcranial Magnetic Stimulation to Treat Parkinson's Disease
Principal Investigator: David H. Benninger, MD.
Completed: September 2009.

Study of Repetitive Transcranial Magnetic Stimulation in Parkinson's Disease.
Principal Collaborator: National Institute of Neurological Disorders and Stroke (NINDS).
Completed: March 2005.

Transcranial Magnetic Stimulation for the Treatment of Parkinson's Disease.
Principal Collaborator: National Institute of Neurological Disorders and Stroke (NINDS).
Completed: September 2000.

Transcranial Magnetic Stimulation in Parkinson's Disease.
Principal Investigator: National Institute of Neurological Disorders and Stroke (NINDS).
Completed: August 2003.

Magnetic Stimulation for Parkinson Disease.
Principal Investigator: National Center for Complementary and Integrative Health (NCCIH).
Completed: April 2005.

Subthalamic Deep Brain Stimulation (DBS) in Parkinson's Disease.
Principal Investigator: Aparna Wagle Shukla, MD.
Completed: June 2016.

Investigating the Safety of srTMS in the Treatment of Parkinson's Disease.
Principal Investigator: National Institute of Neurological Disorders and Stroke (NINDS).
Completed: April 2009.

Study on the Effect of External Magnetic Stimulation on Patients With Parkinson's Disease.
Principal Investigator: John E Duda, MD, et al.
Completed: May 2011.

rTMS for Motor and Mood Symptoms of Parkinson's Disease.
Principal Investigator: Alvaro Pascual-Leone, MD, PhD, et al.
Completed: June 2014.

Motor Skill Learning in People With Parkinson's Disease.
Principal Collaborator: National Institute of Neurological Disorders and Stroke (NINDS).
Completed: October 2008.

Expectation and Response to Levodopa and Acupuncture in Parkinson's Disease.
Principal Investigator: Jou-Shin Lou, MD, PhD.
Completed: February 2007.

Effect of Levodopa on Postural Motor Learning in Parkinson Disease.
Principal Investigator: Daniel S. Peterson, PhD, MS.
Completed: September 2016.

Motor Cortex Reward Signaling in Parkinson Disease.
Principal Collaborator: National Institute of Neurological Disorders and Stroke (NINDS).
Completed: June 2011.

Principal Collaborator: National Institute of Neurological Disorders and Stroke (NINDS).
Completed: December 2008.

Effects of Brain Stimulation on Learning and Reasoning.
Principal Collaborator: National Institute of Neurological Disorders and Stroke (NINDS).
Completed: December 2003.

Principal Investigator: Mark Hallett, MD.
Completed: n/a.

Principal Investigator: Thomas H. Mareci, PhD.
Completed: July 2017.

1 Dropped Study on treating Parkinson's Disease using Transcranial Magnetic Stimulation in the U.S.

Principal Collaborator: VA Office of Research and Development.
Status: The comorbid Parkinson's disease requirement was dropped from this study.
Completed: June 2009.

8 Current Studies on treating Parkinson's Disease using Transcranial Magnetic Stimulation in the U.S.

Exercise and Transcranial Magnetic Stimulation: Increasing Brain Plasticity in Parkinson's Disease.
Principal Investigator: Alessandro Di Rocco, MD.
Status: Recruiting.
Estimated Completion: November 2018.

Non-Invasive TMS Neuromodulation for Enduring Balance & Locomotion Restoration in Parkinson's Disease.
Principal Investigator: Milton Biagioni.
Status: Recruiting.
Estimated Completion: March 2018.

Conditions- Parkinson Disease.
Principal Collaborator: Le Bonheur Children's Hospital.
Status: Recruiting.
Estimated Completion: March 2018.

Effects of Neuromodulation and Rehabilitation of the Locomotor Network in Freezing of Gait.
Principal Investigator: Gonzalo Revuelta, DO.
Status: Recruiting.
Estimated Completion: August 2018.

Principal Collaborator: National Institute of Neurological Disorders and Stroke (NINDS).
Status: Active, not recruiting.
Estimated Completion: January 2019.

Principal Investigator: Benzi Kluger, MD.
Status: Active, not recruiting.
Estimated Completion: December 2017.

Remotely-supervised Transcranial Direct Current Stimulation (tDCS) for At-home Treatment of Fatigue and Cognitive Slowing in Parkinson's Disease.
Status: Recruiting.
Principal Investigator: Milton Biagioni, MD.
Estimated Completion: May 2018.

Principal Investigator: Krystal L. Parker, PhD.
Status: Recruiting.
Estimated Completion: August 2021.

Total Clinical Trials

There is a record of nearly 900 clinical trials in the U.S. alone that has studied the effects and treatments of Parkinson's Disease. At this time 19 trials in the U.S. have been completed on the potential for transcranial magnetic stimulation interventions to reduce symptoms, with 8 additional studies underway in the recruitment or active stages.
Part
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Part
03

Transcranial Magnetic Stimulation - Clinical Trials for Treating Pain (including fibromyalgia patients)

The total number of current, as well as completed clinical trials, using Transcranial Magnetic Stimulation (TMS) in the US is 22. There were eight current studies, of which six were recruiting and two were active and no longer recruiting. There were eight completed clinical trials using TMS, only two of which included fibromyalgia patients.

Clinical trials for treating pain using tms

The National Institute of Health maintains a web-based resource, ClinicalTrials.gov, of clinical research studies taking place in the United States. It is maintained by the National Library of Medicine (NLM) at the National Institute of Health (NIH). The information is provided by the sponsor or principal investigator of the study and is easily accessible.

I started my search for clinical trials for the treatment of pain using Transcranial Magnetic Stimulation. The results showed 22 completed and current trials. I narrowed my search based on status, which then revealed eight completed studies and eight current studies. Two of the current studies were active and not recruiting, while six trials were recruiting. Another six clinical trials were either terminated, withdrawn or status unknown and were left out of the study.

When specifying fibromyalgia in the search, no clinical trials were found, although 65 overall fibromyalgia clinical trials were found. Once investigating further, two of the completed clinical trials using TMS included fibromyalgia patients.

Current Clinical Trials for Treating Pain with TMS

Recruiting Status

The following six are the clinical trials which have the status "recruiting". The format below is "study name — date — lead researcher", the information was completed as far as possible.
1. Complex Oro-Facial Pain: Functional Imaging Characterization and Treatment With Transcranial Magnetic Stimulation — August 2016 — Stephen J Haines, MD, University of Minnesota, Clinical and Translational Science Institute
2. Transcranial Magnetic Stimulation (TMS) for Complex Regional Pain Syndrome (CRPS) — April 24, 2017 — Sean Mackey, Chief, Division of Pain Medicine, Stanford University

3. Repetitive Transcranial Magnetic Stimulation (rTMS) to Treat Oxaliplatin-Induced Neuropathy — July 10, 2017 — Sarah Prinsloo, PHD, M.D. Anderson Cancer Center

4. Randomized Trial of 1 Hz Versus 10 Hz Right Prefrontal Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Post traumatic Stress Disorder (PTSD) — June 2014 — F. Andrew Kozel, M.D., M.S.C.R., James A. Haley VAH
5. Long Term Efficacy of rTMS in Managing MTBI-related Headache — January 1, 2018 — Albert Yick Leung, MD, VA San Diego Healthcare System, San Diego, CA
6. Can rTMS Enhance Somatosensory Recovery After Stroke? — June 1, 2015 — Svetlana Pundik, MD., Louis Stokes VA Medical Center, Cleveland, OH

Active not Recruiting Status

The following two are the clinical trials which have the status "active not recruiting".

1. Repetitive Transcranial Magnetic Stimulation as Treatment for Acute Suicidality in Adult Patients — May 22, 2017 — Pedro L Delgado, MD, University of Arkansas
2. Repetitive Transcranial Magnetic Stimulation to Improve Cognitive Function in TBI — October 1, 2014 Maheen M Adamson, PhD, VA Palo Alto Health Care System, Palo Alto, CA

Completed Clinical Trials for Treating Pain with TMS

The following eight are the clinical trials which have the status "completed". Only the first two trials include patients with fibromyalgia.

1. Transcranial Magnetic Stimulation (TMS) in the Treatment of Chronic Widespread Pain (CWP) — February 2008 — David H. Avery, MD, University of Washington (including Fibromyalgia patients).
2. Treatment of Fibromyalgia Using Deep Shaped-Field (DSF) Transcranial Magnetic Stimulation (TMS): A Clinical Feasibility Study - August 2010 — M. Bret Schneider, M.D., Clevre Neurotech, Inc.
3. Phantom Pain: A Therapeutic Trial Using Transcranial Magnetic Stimulation — December 1998 — National Institute of Neurological Disorders and Stroke (NINDS)

4. The Effect of 10-Day Treatment of Repetitive Transcranial Magnetic Stimulation on Abdominal Pain in Patients With Chronic Pancreatitis — November 2004 — Steven D Freedman, MD, PhD., Beth Israel Deaconess Medical Center
5. The Effect of a 10-day Course of Transcranial Magnetic Stimulation on Abdominal Pain in Patients With Locally Advanced and Advanced Pancreatic Cancer, a Randomized Phase II Study — May 2006 — Felipe Fregni, MD, PhD., Beth Israel Deaconess Medical Center

6. Phase III Randomized Double-Blind Parallel Group Sham-Controlled Study Evaluating the Efficacy and Safety of Non-invasive Non-repetitive Transcranial Magnetic Stimulation (TMS) for the Acute Preemptive Treatment of the Aura Phase of Migraine Headache — August 2006 — Richard B Lipton, MD., Albert Einstein College of Medicine, Inc.

7. Transcranial Magnetic Stimulation for CRPS — February 2014 — Stanford University
8. Treatment of Thalamocortical Dysrhythmia Using External Neuromodulation to Facilitate the Therapeutic Effect of Ketamine — January 2011 — Steven R Devore Best, M.D., The Neuroscience Center

CONCLUSION

In conclusion, there were 22 clinical trials found using Transcranial Magnetic Stimulation for treating pain, 6 of which are completed and 6 that are in progress. 6 clinical trials have been withdrawn, terminated or status unknown. It would seem TMS could be used for numerous diseases and conditions which result in pain.
Part
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Part
04

Transcranial Magnetic Stimulation - Clinical Trials for Treating Major Depressive Disorder

This brief identifies 39 complete and current/active clinical trials on Transcranial Magnetic Stimulation (TSM) treatments for major depressive disorders in the United States (US). The list is compiled from search results of "ClinicalTrials.gov, a database of privately and publicly funded clinical studies" from across the globe. This database is made available by the United States National Library of Medicine, and provides information on "269,304 research studies in all 50 states and in 203 countries," making it a reliable and comprehensive source for data on clinical trials in the US.

For the purposes of this request, search results were filtered by condition, the relevant medical term and country. The combined filter used to produce data for this write-up was "Major Depressive Disorder" for condition, "Transcranial Magnetic Stimulation" for the medical term and "United States" for country. Clinical trials were then selected from the resulting data on the basis of each trial's recruitment status, classified as either completed or active.

Completed Clinical Trials

A total of 20 relevant clinical trials with a completed recruitment status were identified. Details of the official title, lead researcher and dates for each trial are presented below.

1.
OFFICIAL TITLE
Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Panic Disorder (PD) With Comorbid Major Depression

RESEARCH LEAD
Antonio Mantovani, MD, Columbia University

DATES
Study Start Date: October 2007
Primary Completion Date: June 2011
Study Completion Date: June 2011

2.
OFFICIAL TITLE
5Hz Repetitive Transcranial Magnetic Stimulation for Post-traumatic Stress Disorder Comorbid With Major Depressive Disorder

RESEARCH LEAD
Linda L Carpenter, M.D. Butler Hospital

DATES
Study Start Date: October 2014
Primary Completion Date: April 22, 2016
Study Completion Date: April 22, 2016

3.
OFFICIAL TITLE
Transcranial Magnetic Stimulation in Pregnant Women With Depressive Disorder

RESEARCH LEAD
Deborah R Kim, M.D., Penn Center for Women's Behavioral Wellness

DATES
Study Start Date: November 2011
Primary Completion Date: July 2016
Study Completion Date: January 2017

4.
OFFICIAL TITLE
An Open-Label Eight-Week Trial of Repetitive Transcranial Magnetic Stimulation in Depressed Adolescents: Mechanisms of Response

RESEARCH LEAD
Paul E Croarkin, DO Mayo Clinic

DATES
Study Start Date: December 2011
Primary Completion Date: May 2013
Study Completion Date: December 2013

5.
OFFICIAL TITLE
Neurophysiologic Predictors of Outcome With rTMS Treatment of Major Depressive Disorder

RESEARCH LEAD
Ian A Cook, MD, UCLA Depression Research and Clinic Program

DATES
Study Start Date: July 2009
Primary Completion Date: September 2011
Study Completion Date: October 2011

6.
OFFICIAL TITLE
Determining Effectiveness of Multi-Coil rTMS for Patients With Major Depressive Disorder: A Pilot Study

RESEARCH LEAD
Paul E Croarkin, D.O., Mayo Clinic

DATES
Study Start Date: October 2011
Primary Completion Date: October 2013
Study Completion Date: October 2013

7.
OFFICIAL TITLE
A 12-Month Prospective Randomized Dual-Arm Pilot Study of Maintenance NeuroStar Transcranial Magnetic Stimulation (TMS) in Patients With Major Depressive Disorder

RESEARCH LEAD
David G. Brock, MD, Neuronetics

DATES
Study Start Date: August 2011
Primary Completion Date: September 2013
Study Completion Date: July 2014

8.
OFFICIAL TITLE
A Randomized, Parallel-Group, Sham-Controlled, Multi-Center Study to Evaluate the Safety and Efficacy of the Neuronetics Model 2100 CRS Repetitive Transcranial Magnetic Stimulation (rTMS) System in Patients With Major Depression

RESEARCH LEAD

DATES
Study Start Date: January 2004
Primary Completion Date: November 2005
Study Completion Date: November 2005

9.
OFFICIAL TITLE
A Prospective Multicenter Double Blind Randomized Controlled Trial to Explore the Tolerability, Safety and Efficacy of the H-Coil Deep Transcranial Magnetic Stimulation (TMS) in Subjects With Major Depression Disorder (MDD)

RESEARCH LEAD
Yechiel Levkovitz, MD, Shalvat Mental Health Center
Abraham Zangen, Dr., Weizmann Institute of Science

DATES
Study Start Date: September 2009
Primary Completion Date: March 2012
Study Completion Date: June 2012

10.
OFFICIAL TITLE
A Pilot Study on Repetitive Transcranial Magnetic Stimulation (rTMS) for Treatment of Bipolar Depression

RESEARCH LEAD
Guohua Xia, MD, PhD, Department of Psychiatry and Behavioral Sciences, UC Davis

DATES
Study Start Date: May 2008
Primary Completion Date: July 2009
Study Completion Date: April 2010

11.
OFFICIAL TITLE
Evaluation of Low Emission NeoSync EEG Synchronized TMS Technology for the Treatment of Major Depressive Disorder: A Multicenter, Randomized, Double-Blind, Sham-Controlled, Trial

RESEARCH LEAD
Andrew Leuchter, MD, UCLA Depression Research & Clinic Program

DATES
Study Start Date: May 2012
Primary Completion Date: August 2013
Study Completion Date: September 2013

12.
OFFICIAL TITLE
Evaluation of rTMS in the Treatment of Mood Disorders

RESEARCH LEAD

DATES
Study Start Date: May 1996
Estimated Study Completion Date: July 2006

13.
OFFICIAL TITLE
An Open-Label Study to Evaluate the Efficacy and Safety of the Neuronetics NeuroStar TMS Therapy System in Patients With Major Depressive Disorder (MDD) With Postpartum Onset.

RESEARCH LEAD
David Brock, MD, Neuronetics, Inc.

DATES
Study Start Date: December 2013
Primary Completion Date: July 2015
Study Completion Date: August 2015

14.
OFFICIAL TITLE
A Causal Neural Network-level Understanding of Depression and Its Treatment Through Concurrent TMS and fMRI

RESEARCH LEAD
Amit Etkin, Stanford University

DATES
Study Start Date: September 2012
Primary Completion Date: January 20, 2017
Study Completion Date: January 20, 2017

15.
OFFICIAL TITLE
A Prospective, Double-Blind, Randomized, Parallel-Group, Sham-Controlled Feasibility Trial of Multi-Coil Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Major Depressive Disorder

RESEARCH LEAD
Beth Stannard, BS, CCRP, CCRC, Cervel Neurotech

DATES
Study Start Date: July 2013
Primary Completion Date: June 2014
Study Completion Date: July 2014

16.
OFFICIAL TITLE
CSP #556 — The Effectiveness of rTMS in Depressed VA Patients

RESEARCH LEAD
Jerome A. Yesavage, MD, VA Palo Alto Health Care System, Palo Alto, CA

DATES
Actual Study Start Date: July 2, 2012
Primary Completion Date: February 15, 2017
Study Completion Date: March 31, 2017

17.
OFFICIAL TITLE
Imaging Biomarkers for TMS Treatment of Depression

RESEARCH LEAD
Stephan F Taylor, MD, University of Michigan

DATES
Study Start Date: September 2013
Primary Completion Date: January 2016
Study Completion Date: April 2016

18.
OFFICIAL TITLE
Transcranial Magnetic Stimulation (TMS) in the Treatment of Chronic Widespread Pain (CWP)

RESEARCH LEAD
David H. Avery, MD, University of Washington

DATES
Study Start Date: February 2008
Primary Completion Date: December 2010
Study Completion Date: December 2010

19.
OFFICIAL TITLE
NeuroStar TMS Therapy System: Data Management, Analysis and Reporting Format for Clinical Treatment Utilization and Outcomes (Protocol no. 19-50001-000,Rev D)

RESEARCH LEAD
Mark Demitrack, MD, Neuronetics, Inc.

DATES
Study Start Date: March 2010
Primary Completion Date: September 2012
Study Completion Date: September 2012

20.
OFFICIAL TITLE
Nonconvulsive Electrotherapy: a Proof-of-concept Trial

RESEARCH LEAD
William T Regenold, Associate Professor of Psychiatry, University of Maryland

DATES
Study Start Date: May 2010
Primary Completion Date: March 2014
Study Completion Date: April 2014

Active Clinical Trials

Relevant clinical trials that were identified with an active status are 19 in total. The recruitment status of active trials can fall under the categories of recruiting, enrolling by invitation, and not recruiting. As such, details of the official title, lead researcher and dates for each active clinical trial are presented below under the status subcategories of active, recruiting and active, not recruiting.

ACTIVE, RECRUITING (INCLUDING ENROLLING BY INVITATION) CLINICAL TRIALS:

1.
OFFICIAL TITLE
Treatment of Depression With Connectivity Guided Robotically Delivered Repetitive Transcranial Magnetic Stimulation

RESEARCH LEAD
Felipe S Salinas, PhD The University of Texas Health Science Center at San Antonio

DATES
Actual Study Start Date: August 17, 2017
Estimated Primary Completion Date: July 2020
Estimated Study Completion Date: July 2020

2.
OFFICIAL TITLE
Transcranial Magnetic Stimulation in Pregnant Women With Depressive Disorder

RESEARCH LEAD
Deborah R Kim, M.D. Penn Center for Women's Behavioral Wellness

DATES
Study Start Date: November 2011
Primary Completion Date: July 2016
Study Completion Date: January 2017

3.
OFFICIAL TITLE
A Randomized, Double-Blinded, Sham-Controlled Trial of Repetitive Transcranial Magnetic Stimulation in Depressed Adolescents (Part 1)

RESEARCH LEAD
Paul E Croarkin, DO Mayo Clinic
Mark A George, MD Medical University of South Carolina

DATES
Study Start Date: April 2013
Estimated Primary Completion Date: December 2018
Estimated Study Completion Date: December 2018

4.
OFFICIAL TITLE
A Randomized, Double-Blinded, Sham-Controlled Trial of Repetitive Transcranial Magnetic Stimulation in Depressed Adolescents (Part 2)

RESEARCH LEAD
Paul E Croarkin, DO Mayo Clinic
Mark A George, MD Medical University of South Carolina

DATES
Study Start Date: March 2013
Estimated Primary Completion Date: December 2018
Estimated Study Completion Date: December 2018

5.
OFFICIAL TITLE
fMRI-neuronavigated Repetitive Transcranial Magnetic Stimulation for the Treatment of Major Depression Associated With Traumatic Brain Injury

RESEARCH LEAD

DATES
Study Start Date: August 2016
Estimated Primary Completion Date: August 2019

6.
OFFICIAL TITLE
Concurrent fMRI-guided rTMS and Cognitive Therapy for the Treatment of Major Depressive Episodes

RESEARCH LEAD
Sarah H Lisanby, MD, National Institute of Mental Health (NIMH)

DATES
Anticipated Study Start Date: March 29, 2018
Estimated Primary Completion Date: January 31, 2019
Estimated Study Completion Date: January 31, 2019

7.
OFFICIAL TITLE
Cortical Excitability and Inhibition in Children and Adolescents With Major Depressive Disorder

RESEARCH LEAD
Paul E Croarkin, D.O., Mayo Clinic

DATES
Study Start Date: October 2012
Estimated Primary Completion Date: August 2018
Estimated Study Completion Date: August 2018

8.
OFFICIAL TITLE
A Prospective Multicenter Double Blind Randomized Controlled Trial to Demonstrate That the Efficacy of the H7-Coil is as Good as the Efficacy of the H1-Coil Deep Transcranial Magnetic Stimulation (DTMS) in Subjects With Major Depression Disorder (MDD)

RESEARCH LEAD

DATES
Actual Study Start Date: March 30, 2017
Estimated Primary Completion Date: January 2019
Estimated Study Completion Date: April 2019

9.
OFFICIAL TITLE
Longitudinal, Prospective Study to Examine the Brain-based Biomarkers of Response to Transcranial Magnetic Stimulation Treatment in Major Depressive Disorder

RESEARCH LEAD
Amit Etkin, MD PhD, Stanford University

DATES
Study Start Date: July 2016
Estimated Primary Completion Date: July 2018

10.
OFFICIAL TITLE
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder

RESEARCH LEAD
Carlos A Zarate, MD, National Institute of Mental Health (NIMH)

DATES
Actual Study Start Date: May 25, 2017
Estimated Primary Completion Date: July 1, 2018
Estimated Study Completion Date: July 1, 2018

11.
OFFICIAL TITLE
Glutamate Probes in Adolescent Depression

RESEARCH LEAD
Paul E Croarkin, DO, Mayo Clinic

DATES
Actual Study Start Date: August 1, 2014
Estimated Primary Completion Date: December 31, 2018
Estimated Study Completion Date: March 31, 2019

12.
OFFICIAL TITLE
A Prospective, Multicenter, Double-Blind, Sham-Controlled Adaptive Design Study to Confirm the Safety and Efficacy of NEST sTMS in Subjects With Major Depressive Disorder Who Have Not Responded to at Least One Antidepressant Medication in the Current Episode

RESEARCH LEAD
Andrew Leuchter, MD, University of California, Los Angeles

DATES
Actual Study Start Date: November 27, 2017
Estimated Primary Completion Date: December 2018
Estimated Study Completion Date: February 2019

13.
OFFICIAL TITLE
Accelerated TMS to a Novel Brain Target in MDD and PTSD

RESEARCH LEAD
Desmond Oathes, PhD, University of Pennsylvania

DATES
Actual Study Start Date: April 20, 2017
Estimated Primary Completion Date: November 2018
Estimated Study Completion Date: November 2018

14.
OFFICIAL TITLE
Transcranial Magnetic Stimulation for Adults With Autism Spectrum Disorder and Depression

RESEARCH LEAD
McLeod F Gwynette, MD, Medical University of South Carolina

DATES
Study Start Date: September 2016
Estimated Primary Completion Date: July 2017
Estimated Study Completion Date: September 2017

15.
OFFICIAL TITLE
Augmentation Versus Switch: Comparative Effectiveness Research Trial for Antidepressant Incomplete and Non-responders With Treatment Resistant Depression (ASCERTAIN-TRD)

RESEARCH LEAD
George I. Papakostas, MGH Clinical Trial Network and Institute (CTNI), Massachusetts General Hospital

DATES
Actual Study Start Date: May 1, 2017
Estimated Primary Completion Date: October 2021
Estimated Study Completion Date: January 2022

16.
OFFICIAL TITLE
Accelerated Theta Burst Stimulation in Treatment-Resistant Depression

RESEARCH LEAD
Nolan Williams, MD, Palo Alto, California

DATES
Actual Study Start Date: May 1, 2017
Estimated Primary Completion Date: September 30, 2019
Estimated Study Completion Date: September 30, 2020

17.
OFFICIAL TITLE
Evaluation of NeoSync EEG Synchronized TMS For the Treatment of Major Depressive Episode in Bipolar Disorder and Associated Neural Response: An Open Label Trial

RESEARCH LEAD
Linda Carpenter, MD, Butler Hospital,

DATES
Study Start Date: May 2016
Estimated Primary Completion Date: June 2018
Estimated Study Completion Date: October 2018

ACTIVE, NOT RECRUITING CLINICAL TRIALS:

1.
OFFICIAL TITLE
Investigation of Cortico-limbic Networks and Their Dynamics in Major Depressive Disorder

RESEARCH LEAD
Mark C Eldaief, M.D., Brigham and Women's Hospital

DATES
Study Start Date: February 2013
Estimated Primary Completion Date: December 2017
Estimated Study Completion Date: July 2018

2.
OFFICIAL TITLE
A Randomized, Sham-Controlled Trial Evaluating the Safety and Effectiveness of NeuroStar® Transcranial Magnetic Stimulation (TMS) Therapy in Depressed Adolescents

RESEARCH LEAD
Paul Croarkin, MD, Mayo Clinic

DATES
Study Start Date: October 2015
Estimated Primary Completion Date: January 2018
Estimated Study Completion Date: December 2018

Conclusion

According to ClincalTrials.gov, there are 39 clinical trials in the US with a recruitment status of complete and current/active. Slightly over half or 20 of these are complete, 17 are active and recruiting while the remaining 2 are active and not recruiting.
Part
05
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Part
05

Transcranial Magnetic Stimulation - Clinical Trials for Treating Schizophrenia

Based on the information available in the FDA's Clinical Trials website and the contents of a 2015 peer-reviewed paper which surveyed the then-available clinical trials on the subject, we were able to locate 21 clinical trials which have studied the use of Transcranial Magnetic Stimulation (TMS) to treat schizophrenia.
Below you will find a list of each study, when it took place, the principal investigator (aka lead researcher). Due to the fact that some of these studies are ongoing, we have provided both the start and completion dates where available and so have modified the requested format to include both. As the university and/or hospital used in each study was readily available, we have included this information as well.

A NOTE ON DEFINITIONS

As we reviewed the scientific literature on this subject, we found that in many cases, the article in question referred to "studies" instead of "clinical trials." However, a clinical trial technically refers to the test of any "intervention -- a potential drug, medical device, activity, or procedure -- in people." Therefore, unless the context of a given study makes it clear that the study in question is a review of multiple clinical trials (as is the case for one of our best compilation sources, for example), we did not separate "studies" of Transcranial Magnetic Stimulation (TMS, henceforth) from "clinical trials" based only on the author's preferred term.
Also note that due to the nature of the request, we did not limit ourselves to material published in the last two years as per Wonder's standard procedure.

clinical trials website

According to the FDA's official clinical trial repository, there have been 19 clinical trials testing TMS for schizophrenia in the United States since 2002. (Note: The search page says 21, but two were unrelated and so have been removed.) Per the request specifications, we will list them below, but we have also exported the list into this attached spreadsheet for your convenience.
Treatment of Negative Symptoms of Schizophrenia With Transcranial Magnetic Stimulation (TMS). - Arielle D. Stanford. This study began in 2004 and was eventually terminated due to being unable to adequately recruit subjects.
Cerebellar rTMS for the Treatment of Schizophrenic Patients. - Alvaro Pascual-Leone (2008-2009)
TMS Enhancement of Visual Plasticity in Schizophrenia. - Laura M Rowland (2017, ongoing)
Transcranial Magnetic Stimulation for "Voices." - Ralph E. Hoffman (2006-2012)
TMS for Symptom Reduction in Schizophrenia. - L.E. Hong (2016, ongoing)
Theta Burst Stimulation for Schizophrenia. - Gopalkumar Rakesh (2017, ongoing)
Circuitry-Guided Smoking Cessation in Schizophrenia. - Xiaoming Du. This study only began on March 1, 2018 and is not yet recruiting.
Treating Refractory Schizophrenia With rTMS. - Robert Buchanan (2014, ongoing)
rTMS in First Episode Psychosis. - Michael Francis (2014-2016)
Cerebellar Stimulation and Cognitive Control. - Krystal L Parker (2017, ongoing)
In Vivo Imaging of Therapeutic Electric Current Flow. - Thomas H Mareci (2015-2017)

OLDER CLINICAL TRIALS

In addition to the above, we located a 2015 peer-reviewed article entitled "Transcranial magnetic stimulation (TMS) for schizophrenia." This work compiled data from the Cochrane Schizophrenia Group Trials Register going up to April 2013 and discovered that there had been 41 studies totaling 1473 participants published up to that point. Only two of the 41 trials took place in the USA (three more took place in Canada). Below is the information provided in the article's bibliography:
Hoffman RE, Gueorguieva R, Hawkins KA, Varanko M, Boutros NN, Wu Y, et al. Temporoparietal transcranial magnetic stimulation for auditory hallucinations: safety, efficacy and moderators in a fifty patient sample. Biological Psychiatry 2005;58(2):97-104.
Schneider A, Schneider T, Stark H. Repetitive transcranial magnetic stimulation (rTMS) as an augmentation treatment for the negative symptoms of schizophrenia: A 4-week randomized placebo controlled study. Brain Stimulation 2008;1(2):106-11.
Due to the information not mapping perfectly to that from the Clinical Trials website, we have not attempted to add these two studies to the spreadsheet. We searched, but did not find a more recent article along similar lines. We attempted to access the Cochrane Schizophrenia Group Trials Register to obtain the latest information, but this register is not open to the public.

CONCLUSION

All told, we were able to locate twenty-one clinical trials on the use of Transcranial Magnetic Stimulation (TMS) to treat schizophrenia. It may be significant that the 2015 academic paper that based on their review of the available studies, "there is insufficient evidence to support or refute the use of TMS to treat symptoms of schizophrenia." Experts in the field have yet to determine whether the studies conducted after early 2013 lead to a different conclusion.
Sources
Sources

From Part 02
From Part 04
From Part 05