Please help me understand the STEMI vs. NSTEMI disease burden for those with ACS in the US. How many are affected by STEMI and NSTEMI heart attacks in the US each year?
As requested, we have searched for the number of people affected by STEMI and NSTEMI heart attacks in the US each year. Although a comprehensive report with the exact number of people with these type of heart attacks could not be found, several reports and academic studies have been found revealing a number of relevant statistics. The data for STEMI heart attacks was found in the reports whereas, for NSTEMI, we have calculated the number of people affected with the disease with the help of other relevant statistics.
A 2014 article published in MedPage Today states that an ACS (Acute Coronary Syndrome) incidence occurs every 25 seconds in the US, and "an ACS-related death occurs every minute".
Due to the aging population, decrease in smoking, and increased use of statin drugs, STEMI is declining while NSTEMI is taking the dominant spot among ACS patients. STEMI is usually seen in middle age, while NSTEMI is present in the elderly.
Another study published in the Annals of Transnational Medicine, 2016 confirms that "there has been a relative increase in non-ST elevation MI (NSTEMI) in relation to ST elevation MI (STEMI) with time".
Number of People Affected with STEMI vs NSTEMI
Although we could not find a comprehensive report revealing the number of people affected by STEMI and NSTEMI heart attacks in the US each year, we have gathered some relevant statistics. We found some studies published in the year 2015 and 2017 quoting the old statistics related to the number of people with STEMI & NSTEMI. For STEMI, I found a recent report providing the number of incidences each year in the US.
Recently, a study done by Mayo Foundation for a period of 2003 to 2010 revealed that approximately 1.99 million patients over 18 years of age have been diagnosed with STEMI throughout 8 years.
According to an article published in the Cesca Therapeutics (2017), 720,000 people in the US have an AMI (Acute Mayocardial Infarction) each year. The incidence of ST-Elevated Myocardial Infarction (STEMI) is estimated as 77 per 100,000 total inhabitants.
And the total US population is 327,651,541 (2017).
So, after calculation the number of people with STEMI would be:
A 2015 study published in the BioMed Research International mentioned some old but relevant data related to the incidence of STEMI & NSTEMI in the US. It has quoted that "the incidence rates of STEMI declined appreciably (121 to 77 per 100,000), whereas the incidence rates of NSTEMI increased slightly (126 to 132), between 1997 and 2005.
According to the American Heart Association Fact Sheet, there are approximately 931,000 people suffer from heart attacks in the US each year. Of those 931,000 people, about 250,000 patients are affected by STEMI (an ST-elevated myocardial infarction). It is a severe type of heart attack caused by the sudden, total blockage of a coronary artery.
A 2015 report published by the Truven Health Analytics the American College of Cardiology Foundation reports quoted the information provided by the American College of Cardiology Foundation (ACCF). It states that "30 to 40% of patients diagnosed with unstable angina based on CPK or creatine phosphokinase results are now being diagnosed with NSTEMI". Therefore, it is estimated that 30%-40% of patients diagnosed with MI are classified as NSTEMI.
According to the American Heart Association Fact Sheet, there are approximately 931,000 people suffer from heart attacks in the US each year. As heart attack is also referred as Mayocardial Infarction (MI). Therefore, the number of people suffering from NSTEMI would be calculated as:
= 0.28 million to 0.37 million people
Based on the above data and calculation, it is estimated that the number of people affected by STEMI is 0.25 million whereas, for NSTEMI, the total number of affected people is 0.28 million to 0.37 million in the US each year. Also, it has been observed that the rate of incidence for STEMI is declining.