Key Takeaways

•  PMC published the findings of a study titled, 'R-CHOP 14 with or without radiotherapy in non-bulky limited-stage diffuse large B-cell lymphoma'. The study was published in 2018 and in the abstract, it was indicated that 'The patients received 4 or 6 consecutive cycles of R-CHOP delivered once every 2 weeks, followed or not by RT at 40 Gy delivered 4 weeks after the last R-CHOP cycle'.

•  ASH Publications published a paper titled. 'R-CHOP 14 with or without radiotherapy in non-bulky limited-stage diffuse large B-cell lymphoma'. In the paper, it was reported that about 334 patients were involved in the study and the patients received 4 or 6 consecutive cycles of R-CHOP. Thereafter, some patients had subsequent treatment with radiation whereas others were not subjected to radiation.
• The International Journal of Radiation Oncology published an article titled, 'The Role of Consolidative Radiotherapy after Complete Remission to R-CHOP Immunochemotherapy in Stage III-IV Diffuse Large B-Cell Lymphoma: A Single Institutional Experience'. The study involved about 407 patients and the report indicated that some patients received R-CHOP treatment without radiation and others received R-CHOP with subsequent radiation.

Introduction

4 Cycles of R-CHOP Without Radiation Compared to 6 Cycles of R-CHOP Without Radiation

•  PMC published the findings of a study titled, 'R-CHOP 14 with or without radiotherapy in non-bulky limited-stage diffuse large B-cell lymphoma'. The study was published in 2018 and in the abstract, it was indicated that 'The patients received 4 or 6 consecutive cycles of R-CHOP delivered once every 2 weeks, followed or not by RT at 40 Gy delivered 4 weeks after the last R-CHOP cycle'.
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•  The Lancet quotes a paper titled, 'Four versus six cycles of CHOP chemotherapy in combination with six applications of rituximab in patients with aggressive B-cell lymphoma with favorable prognosis (FLYER): a randomized, phase 3, non-inferiority trial'. This paper whose reference is Lancet. 2019; 394: 2271-2281 was authored by Poeschel V, Ziepert M. and Geld G.

4 Cycles of R-CHOP With and Without Subsequent Radiation

• The Dove Medical Press reported on a paper titled, 'Switching Fractioned R-CHOP Cycles to Standard R-CHOP Cycles Guided by Endoscopic Ultrasonography in Treating Patients with Primary Gastric Diffuse Large B-Cell Lymphoma'. The authors of this paper were Liu Y, Liu Y, Zhao P, Zhang Q, Liu X, Lv F, Hong X, Cao J, and Xue K. The study involved about 31 patients and 4 of the patients got 4 cycles of fractioned R-CHOP.  
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•  ASH Publications published a paper titled. 'R-CHOP 14 with or without radiotherapy in non-bulky limited-stage diffuse large B-cell lymphoma'. In the paper, it was reported that about 334 patients were involved in the study and the patients received 4 or 6 consecutive cycles of R-CHOP. Thereafter, some patients had subsequent treatment with radiation whereas others were not subjected to radiation.

•  PMC reported on a paper published in the Korean Journal of Hematology titled, 'Additional rituximab-CHOP (R-CHOP) versus involved-field radiotherapy after a brief course of R-CHOP in limited, non-bulky diffuse large B-cell lymphoma: a retrospective analysis'. The paper reports on the findings of a study that involved about 36 patients subjected to either 3-4 cycles of R-CHOP with subsequent radiation or 6-8 cycles of R-CHOP without radiation.
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6 cycles of R-CHOP With and Without subsequent radiation

•  PMC reported on a paper published in the Korean Journal of Hematology titled, 'Additional rituximab-CHOP (R-CHOP) versus involved-field radiotherapy after a brief course of R-CHOP in limited, non-bulky diffuse large B-cell lymphoma: a retrospective analysis'. The paper reports on the findings of a study that involved about 36 patients subjected to either 3-4 cycles of R-CHOP with subsequent radiation or 6-8 cycles of R-CHOP without radiation.
• The International Journal of Radiation Oncology published an article titled, 'The Role of Consolidative Radiotherapy after Complete Remission to R-CHOP Immunochemotherapy in Stage III-IV Diffuse Large B-Cell Lymphoma: A Single Institutional Experience'. This study involved about 407 patients and the report indicated that some patients received R-CHOP treatment without radiation and others received R-CHOP with subsequent radiation.

Research Strategy