Innovative Treatments for Diabetes
Innovative treatments for type I diabetes include, the Control-IQ System, oxygen-enhanced implantable devices, ultrasounds, stem-cell-derived islets, and anti-thymocyte globulin. Innovated treatments for type II diabetes include blocking VDAC1 proteins, the protein adipsin, reducing or eliminating CD248, EndoBarrier, and Smart Insulin Pumps.
Innovative Treatments for Type I Diabetes
- Tandem's Control-IQ System is an artificial pancreas which uses an algorithm to adjust insulin doses during the day.
- The system was approved in December 2019 and launched in January 2020 in the United States.
Oxygen-Enhanced Implantable Device
- Researchers at the University of Arizona have been working on an oxygen-enhanced implantable device that can sense when insulin is low and release a dose of insulin.
- The device would mean immunosuppression would no longer be necessary.
- Procyon Technologies, LLC will help commercialize the product when it passes clinical trials, which may not be for three to five years.
- Vesna Zderic, a biomedical engineer at George Washington University has been studying the use of ultrasounds to treat type I diabetes.
- Ultrasounds can trigger the brain to release certain chemicals. Beta cells make and release insulin, Zderic found that ultrasounds can trigger beta cells to release insulin in mice.
- Stem-cell-derived islets is a possible innovation for curing type I diabetes. Stem-cell-derived islets can develop into any kind of cell.
- Semma Therapeutics has developed SC-islets that have been transplanted into nonhuman primates and pigs with type 1 diabetes. The trials have produced human insulin in the animals and helped control blood sugar levels.
- In September 2019, Vertex Pharmaceuticals purchased Semma Therapeutics to continue to develop the cells.
- Anti-thymocyte globulin may offer a chance at remission for those effected by type I diabetes. In type I diabetes beta cells are destroyed, anti-thymocyte globulin is a specialized antibody against human T cells.
- Research and clinical trials are being conducted in collaboration with Sanofi, Amgen, National Institute of Diabetes and Digestive and Kidney Diseases, and others.
Innovative Treatments for Type II Diabetes
- Preclinical evidence has found that blocking VDAC1, a protein in insulin-producing beta cells can restore them to normal function in patients with type II diabetes.
- Researchers at Lund University in Sweden are currently investigating the potential of blocking the protein.
The Protein Adipsin
- Researchers have found that the protein adipsin protects pancreatic beta cells from destruction in type II diabetes. The discovery suggests that the protein could be used as a potential therapy for type II diabetes.
- Weill Cornell Medicine is currently conducting research on the possible innovation.
Reducing or Eliminating CD248
- Researchers have found that reducing or eliminating the protein CD248 in fat calls can prevent the onset of type II diabetes and also reverse the disease.
- Researchers at the Centre for Blood Research are currently performing trials in mice.
- EndoBarrier is an endoscopic weight-loss procedure which may be a possible innovative treatment for type II diabetes and obesity. The non-invasive EBMT is currently conducting clinical trials.
- The technology was created by GI Dynamics, a medical device company.