Key Takeaways

•  CSF diversion should be the first line of treatment against iNPH.
• CSF drainage should be used to treat iNPH because it improves stuttering in select circumstances.
•  Motor apraxia seen in iNPH can influence speech production, resulting in stuttering or dysarthria in iNPH

Introduction

2022 Research

•  Title: Investigation of a Valve-Agnostic Cranial Implant for Adult Hydrocephalus Patients Requiring Ventriculoperitoneal Shunting
•  Link 
• Summary: The research investigates how safe and effective the valve-agnostic cranial implant (VACI) is when used to reduce the complication brought by high-profile programmable valve designs in ventriculoperitoneal shunts (VPS). Early results show "promising outcomes with a low complication rate for patients with hydrocephalus undergoing VACI placement during VPS."
•  Title: Sleep-disordered breathing is frequently associated with idiopathic normal pressure hydrocephalus but not other types of hydrocephalus

•  Link
• Summary: The research unveiled the existence of a high prevalence of sleep-disordered breathing (SDB) in patients with idiopathic normal pressure hydrocephalus (iNPH)." The study also found that the prevalence of SDB in patients with various kinds of hydrocephalus is similar to the general population.

2021 Research

•  Title: Increased plasmin-mediated proteolysis of L1CAM in a mouse model of idiopathic normal pressure hydrocephalus
•  Link 
• Summary: The study was done to show the effects that deletions in CWH43 would have on cell adhesion molecule L1CAM in a brain. It concluded that "CWH43 deletions may contribute to adult-onset iNPH by selectively downregulating L1CAM in the ventricular and subventricular zone."
•  Title: Pathogenesis and pathophysiology of idiopathic normal pressure hydrocephalus

•  Link 
• Summary: The research concluded that factors that lead to neurological deficits are not entirely idiopathic. It points out that "etiologic factors and pathophysiological changes might constitute a vicious, deregulating loop" that may finally result in clinical signs of iNPH. The study also hails CSF diversion as the first line of treatment against iNPH even though it carries a risk of possible complications.
•  Title: Vision-based gait analysis system utilizing deep learning algorithms in idiopathic normal-pressure hydrocephalus patients
•  Link 
• Summary: The research uncovered that vision-based gait analysis that utilized deep learning algorithms could "provide comparable data to GAITRite when assessing gait dysfunction in INPH." It also revealed that "frontal lobe functions may be associated with gait variability measurements using vision-based gait analysis for INPH patients."

2020 Research

•  Title: Idiopathic Normal Pressure Hydrocephalus With Stuttering: Report of Two Cases and Review of the Literature

•  Link:
• Summary: The study discovered that the motor apraxia seen in iNPH could influence speech production, resulting in stuttering or dysarthria in iNPH. It also recommends using CSF drainage to treat iNPH because it improves stuttering in select circumstances.

2019 Research

•  Title: The clinical spectrum of hydrocephalus in adults: report of the first 517 patients of the Adult Hydrocephalus Clinical Research Network registry
•  Link 
• Summary: The research concluded that, "the clinical spectrum of hydrocephalus in adults comprises much more than iNPH or acquired hydrocephalus."

Research Strategy