GHD Market Analysis

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01
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Part
01

GHD Market Size

The market size for GHD in 2020 is estimated at $1.65 billion. The number of diagnoses made every year vary between adults and children as well as globally, with estimates as high as 1 per 1,800 children. The earliest age of diagnosis is commonly 5 years of age, with a second diagnostic peak taking place during teenage years.

Key findings

  • The market size for GHD is estimated at $1.65 billion for 2020, with a CAGR of 3.9%. The most recent report estimates this market will grow to $2.08 billion by the end of 2026.
  • Prevalence of GHD is difficult to estimate due to variable diagnosis criteria and the lack of a gold-standard diagnostic test.
  • Studies performed worldwide show an incidence in children as high as 1 per 1,800 children in Sri Lanka, and as low as 1 in 30,000 children in Newcastle, United Kingdom.
  • New onset cases in adults have an estimated incidence of 1.2 per 100,000 adults.
  • In the United States, GHD incidence in adults rises to 2 per 100,000 in adults after patients that were diagnosed as children are included in the criteria.
  • There is a statistically significant difference in the prevalence of GHD between males and females. Studies have shown that 72% of patients are male while 27% are female in idiopathic cases, which are those in which no cause is identified. Moreover, 62% of patients were males and only 38% were female in organic cases.
  • Diagnosis usually take place at two ages. When patients are 5 years old, and when they are 12-16 years old in the case of females and 10-13 years old in the case of males.

Research Strategy

The most recent market size estimation for GHD sales was from 2016, with a calculated growth rate (CAGR) estimated at 3.9%. This CAGR was used to estimate GHD market size in 2020.
Part
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Part
02

GHD Resources

MAGIC Foundation, Child Growth Foundation, Human Growth Foundation, Pediatric Endocrine Society, and Endocrine Society are some organizations providing resources and support for people with or those learning about Growth Hormone Deficiency (GHD). A brief description of each organization is presented below.

MAGIC Foundation

Child Growth Foundation (GCF)

  • CGF is a charity organization based in the United Kingdom. It aims to "manage and support" rare growth conditions in children and adults.
  • The organization's mission is to build a system where care plans and clinical diagnostics can be offered to families, who are affected by growth conditions.
  • GHD is one of the conditions supported by the organization, among other growth conditions.
  • It provides information about the disorder and how to manage it to families.
Human Growth Foundation (HGF)
  • HGF is a "global leader" in endocrine education, research, support, and patient advocacy.
  • The organization was established in 1965 by five families of children affected by growth disorders.
  • One of the services provided by the organization is providing support to parents of children with growth disorders, and supporting adults with GHD.
  • The organization releases publications on GHD in adults and children regularly.
  • HGF's headquarters is located in Glen Head, New York.
Pediatric Endocrine Society (PES)
Endocrine Society
  • Endocrine Society is a "global community" of 18,000 members who are focused on uncovering the mysteries of hormone disorders, to cure diseases and take care of patients.
  • The organization was founded in 1916 and its headquarters is located in Washington, DC.
  • It provides resources for patients with hormone disorders including GHD.


Part
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Part
03

Social Media Scan (2)

Insights surrounding GHD were found surrounding a support association, the effect of HGH on the brain, new methods of administration, GHD and other effects on children and the costs of treatment for GHD.

Growth Awareness Week

  • The MAGIC Foundation is a non-profit charitable organization that provides support services for the families of children with growth disorders.
  • Their motto is, "Children have a short time to grow and a lifetime to live with those results ®."
  • They sponsor an annual convention each year in July and a Growth Awareness Week in September.
  • This event and its media coverage focus on providing information for adults who have children with GHD or adults who are afflicted.

GHD and New Guidelines

New Methods of Administration

GHD and Children

  • There are more complications associated with GHD than just not growing. Children also tend to accumulate fat around the abdomen, and are at risk of unusually low muscle mass and delicate bones.
  • Treatment with growth hormone therapy is designed to restore energy and metabolism as well as improve body development or shape.

GHD and Costs

  • In the US, challenges concerning the coverage of HGH by insurance companies abound. At ENDO 2019: The Endocrine Society Annual Meeting, it was communicated that while the cost of manufacturing HGH has dropped, the cost to patient's families has more than doubled in the past 15 years.
  • Insurance companies regularly amend the "preferred" GH product they will cover, causing hassle for physicians and their staff, in terms of time spent on paperwork and other bureaucracy.
  • These changes can lead to breaks in therapy as patients struggle to navigate different GH brands and their delivery devices."
  • In Australia, one mother wrote on Instagram that she was "feeling very thankful to live in a country that has a PBS. And Growth Hormone is on the list of medications covered. Our new script arrived at the chemist today. The full cost of 3 months' medication is $3,466."


Part
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of four
Part
04

Social Media Scan (1)

A review of social media provided insights into parents and children dealing with GHD. The major categories include side effects, symptoms, support groups, results of treatment, and the effects of the disease on children.

Side effects

  • Some parents on Instagram were nervous about starting their children on HGH and were looking for information on potential side effects from mothers of children currently in treatment.
  • "Hi, there, momma! I’m considering giving my twins norditropin and would love to speak to other moms who are giving it to their children. Would you be open to chatting?"
  • "We just got approved and about to start therapy. I’m a little anxious about side effects I’m hoping they will be minimal. Our little guy will be 8 in August, and most people think he’s six and in kindergarten. How has your experience been with therapy if you don’t mind me asking."

Symptoms

Support

Result of treatment

  • Many original posts were pictures of children with reports on the success of the treatment, as reflected in increased height.
  • "3 years of daily shots of #humotrope and kai finally is on the growth chart! Just the line, but he has grown 9 inches in the last year! That's incredible."
  • "18months of daily growth hormone injections= 12cm growth in height.👍 The previous 18months she only grew 3cm!"

Effects on Children

  • Some posts provide insights into the impact of GHD on children and as well as their thoughts and solutions for dealing with the illness.
  • "Most premature babies catch up by age two, but not Elliot. He finally got tired of people questioning (and not believing) how old he is, so we found ourselves an amazing endocrinologist, and he started growth hormone treatment. After two years, he just hit the second percentile. That's huge for a kid who has never been on the growth chart!"
  • "J.J. started gymnastics. He has been wanting to go, and we were told to push him into strength-building sports. Since he has little to no body fat, but Crazy Upper Body Strength! He is embracing the effects of Growth Hormone. This is an all-boys class, and they are a few years older than him & he did fantastic keeping up with them."
  • "This medication has made a massive difference to our youngest boy. He's grown 15cm in 15 months. He's no longer teased on a daily basis for being small. When I say small, I mean the size of a three-year-old at age 7. When I say teased, I mean tormented — physically bullied. Emotional bullied. Singled out daily for something he had no control over. Taken out of class at school and measured by another teacher because they needed something small to measure. Fifteen months of treatment have seen our boy grow physically. He's also much more peaceful. Less angry at the world. He blends in with his peers at school. Sure he's still shorter than the average, but it's not longer a glaring difference. He's no longer targeted and teased on a daily basis. "
  • "He needs Occupational Therapy to help with his dexterity in his hands because he is on Growth Hormone, so his bones are growing faster than his little brain can adjust..."

Research Strategy

We researched GHD in all the major social media platforms.

Facebook
There are five growth hormone deficiency support groups on Facebook. They include GHD/Growth Hormone Deficient Parent Support-The MAGIC Foundation, Growth Hormone Injections in Children, Childhood Growth Hormone Deficiency Support for Parents, Adult Growth Hormone Deficiency, and Growth Hormone Deficiency Support Group. All but the last one are private groups that must be joined to access the content. The last one has not had any content posted since 2013.

YouTube
The MAGIC Foundation has a YouTube Channel where they provide educational videos, but comments are turned off.

Twitter
The Magic Foundation has a Twitter account on which they regularly post information. They have 1,318 followers. However, there are few comments on the posts.

Instagram
Most of the posts on Instagram with the hashtag #growthhormonedeficiency, or a variation thereof, had posts with pictures of children with GHD. The majority of the insights included above came from responses to original posts.
Sources
Sources