Fresh Frozen Plasma Use in a German Hospital

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Fresh Frozen Plasma Use in a German Hospital

While there is no preexisting information to fully answer your question, we've used the available data to pull together key findings: Fresh frozen plasma (FFP) usage audit in a French hospital, a Swiss hospital, and a group of Finnish hospitals.

Below you'll find an outline of our research methodology to better understand why the information you've requested is publicly unavailable, as well as a deep dive into our findings.

METHODOLOGY

To complete your request, I looked for studies and reports documenting the breakdown of FFP usage in German hospitals. I also searched academic and medical papers databases such as the US National Library of Medicine and National Institutes of Health, WorldwideScience.org, and the international journal database Karger. I found no published German studies or papers detailing a German hospital usage audit of FFP use. The same was true for the resource European Blood Alliance. However, I found older FFP usage audits for hospitals in other European countries.

As stated in your request, I prioritized information around breakdown of FFP use over location and year. Please continue below to see the results of my research.

FFP USAGE AUDIT CASES

■ France
The US National Library of Medicine and National Institutes of Health published the abstract of the 2001 paper "Transfusion of Fresh Frozen Plasma (FFP): Audit of Prescriptions". The study analyzed the FFP usage of a French teaching hospital over the course of a year.

The study authors reported that a significant number of FFP prescriptions were inappropriate and potentially illegal. The inappropriate FFP transfusions were broken down as follows:

• Intensive care patients - 73%
• Cirrhotic patients - 12%
• Patients treated with vitamin K antagonists - 12%
• Obstetric patients - 3%

The study authors concluded that a significant amount of FFP transfusions carried out in the hospital was inappropriate and not in accordance with the legal French guidelines established in 1991.

■ Finland
The University Hospital of Würzburg included the 2006 paper "Population-Based Audit of Fresh Frozen Plasma Transfusion Practices" in its database of medical articles and studies. The 2006 study investigated the use of FFP in 9 Finnish district hospitals during 2002 and 2003.

The study authors reported that they analyzed 11,590 patients who received FFP transfusion during 2002 and 2003. This population represented 71.2% of all FFP transfusions carried out in that year. They reported the top conditions for FFP usage as thus:

• Patients with circulatory disease - 25.8%
• Patients with digestive diseases, mostly liver cirrhosis - 17.2%
• Patients with injury and poisoning - 15.9%

Within this population, 66.9% of transfusions were given to surgical patients.

The study authors concluded that FFP consumption in Finland was normal but does not guarantee best practice since 34.1% of patients who received FFP transfusion did not undergo proper coagulation analysis.

■ Switzerland
The US National Library of Medicine and National Institutes of Health also published the 1983 paper "Use of Fresh Frozen Plasma in a Swiss Hospital District". The paper did not include any details around FFP usage breakdown but identified the hospital department surgery, specifically cardiac surgery, to have increased its consumption of FFP during the years 1977 to 1980. The paper noted that FFP consumption in nonspecialized regional hospitals has increased only to a minor degree compared to the University hospital. The article concluded that as a human product, FFP should be used moderately.

OTHER SOURCES

Below are other sources I have searched for German case studies of hospital FFP usage:

Karger - this international biomedical publisher did not yield any relevant results around FFP usage audit in German hospitals. I used the following terms in my research:

FFP = Gefrorenen Frischplasmen
Hospital = Krankenhaus
usage = Verwendung
audit = Prüfung

European Blood Alliance - has no resources documenting FFP usage in European hospitals.

WorldWideScience.org - this resource is maintained by the U.S. Department of Energy's Office of Scientific and Technical Information. Though it contained several relevant results from India and other Asian countries, it did not yield any results for German hospitals. I did not reference these as they were outside Europe.

CONCLUSION

To wrap up, despite the lack of publicly available information around case studies of FFP usage breakdown in a German hospital in 2017, we used available information to pull together the following findings: 3 papers detailing FFP usage audit in a French hospital, a Swiss hospital, and a group of Finnish hospitals. All papers agreed that FFP usage should be in moderation and carefully considered.
Sources
Sources