INHERITANCE PATTERN AND TRIGGERS

• Aromatase excess syndrome (AEXS) is a rare, genetic condition that is inherited following an autosomal dominant pattern, i.e., the affected individual has one copy of a mutant gene and a normal gene within a pair of autosomal chromosomes.
• In this case, the CYP19A1 gene is the mutant gene. The mutation is either inherited from one affected parent
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  or new genetic changes, i.e., there is no family record of the disorder.
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• For every affected individual, there is a 50% chance that their offspring will inherit the mutant gene.
• While the root cause of AEXS is not entirely understood, the severity of its symptoms, for example, mild to severe gynecomastia, is defined by different mutations.
• Mutation duplications cause mild gynecomastia. However, deletions that lead to chimeric genes would typically present moderate to severe gynecomastia.
• Increased aromatase activity, however, occurs for the same reasons for which testosterone decreases, for example, higher amounts of fatty acid. "Saturated fatty acids stimulate the production of pro-inflammatory mediators by macrophages leading to increased aromatase levels."
• Other factors/triggers leading to higher aromatase activity include age, weight gain, poor nutrition, lack of exercise, and high stress.

PREVALENCE IN THE US

• AEXS prevalence is currently unknown. However, there have been more than 20 described cases (30 males and eight females) in medical literature.

PROGNOSIS

• AEXS, if left untreated, could lead to excessively large breasts with a potential need for surgical attention.
• Without treatment, affected males might have issues with fertility. However, fertility problems associated with the condition are not significant enough to hinder sexual reproduction.
• Gynecomastia is life-long but can be managed/ameliorated using an aromatase inhibitor.
• A likely outcome of the condition is a predominantly short adult stature. However, early detection of AEXS and subsequent treatment might prevent short stature.

CONNECTED CHRONIC DISEASES

• AEXS is linked to "endometriosis and estrogen-dependent cancers such as breast and endometrial cancers."
• Males with high estrogen levels (typically due to increased aromatase activity) are at risk of having diabetes, stroke, prostate, and breast cancers.

ANDROSURGE

 

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WHY IT IS THE BEST

•  AndroSurge was ranked among the top 10 estrogen blockers for 2020.
• It is a natural aromatase inhibitor that combines the anti-estrogen effects of grape seed extract, Rhodiola root extract, and diindolylmethane (DIM).
•  Healthline Media describes grape seed extract, one of the active ingredients in AndroSurge, as a potential natural aromatase inhibitor.
• This product does not use any artificial fillers, preservatives, or food dyes.

• AndroSurge should be taken for 8-12 weeks with a recommended dosage of 1 capsule taken with a glass of water, twice daily and 20 minutes before eating.

• AndroSurge is intended for healthy adults, including men and women. However, it is not recommended for pregnant or lactating women.
•  Grape seed extract present in AndroSurge provides similar benefits for both men and women.

MUSCLE FORCE ESTROTASE

 

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WHY IT IS THE BEST

•  Muscle Force Estrotase was ranked among the top 10 estrogen blockers for 2020.
• It blends natural ingredients such as maca root, chrysin, and grape seed extract, which serve as estrogen blockers and aromatase inhibitors.
• It does not make use of any artificial materials.

• The recommended dosage is three capsules daily.

• According to data from Healthline Media, there are no suggestions as to any differences in the effects of chrysin, maca root, and grape seed extract in men and women.
• Muscle Force Estrotase is not recommended for pregnant or lactating women.

ESTROVOID

 

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WHY IT IS THE BEST

•  EstroVoid was ranked among the top 10 estrogen blockers for 2020.
• It is a natural aromatase inhibitor that uses DIM, a popular estrogen-blocking ingredient, along with herbal compounds such as Rhodiola Rosea, Panax Ginseng, and ashwagandha, among others.

• Consumers will observe the best results by taking one capsule with 8oz of water twice daily (morning and afternoon).

• There are no established differences in EstroVoid's effects on men and women. However, it should not be taken by pregnant or lactating women.

ESTREDUXHP

 

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WHY IT IS THE BEST

•  EstreduxHP was ranked among the top 10 estrogen blockers for 2020.
• It combines potent natural ingredients such as Panax Ginseng, DIM, ashwagandha, and Rhodiola. DIM is the compound found in cruciferous vegetables such as broccoli and maca and is known to lower aromatase activity.

• The recommended dose is 2-4 capsules daily, with 8oz of water.

• This product is for men only.

PRIDE NUTRITION E-BLOCK

 

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WHY IT IS THE BEST

•  Pride Nutrition E-Block was ranked among 2020's top 10 estrogen blockers according to BodyNutrition.
• This product blocks excess estrogen production, serves to balance hormones, and acts as an aromatase inhibitor by combining natural ingredients such as chrysin and DIM.
• It does not make use of any additional fillers.

• The recommended dosage is two capsules taken once daily, i.e., along with the consumer's evening meal.

• Pride Nutrition E-Block is recommended for both men and women.
• In men, it helps to tackle gynecomastia. However, it counters estrogen imbalances for both genders.